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KMID : 1123920080220040884
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Korean Journal of Oriental Physiology and Pathology
2008 Volume.22 No. 4 p.884 ~ p.890
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Effects of Eucommia Ulmoides Oliver and Treadmill Exercise on the Osteoporosis of Rats Caused by Glucocorticoid Induction
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Yoon Seok-Joo
Kim Kyung-Yoon
Kim Gye-Yeop
Nam Ki-Won
Sim Ki-Cheol
Kim Eun-Jung
Jeong Hyun-Woo
Kim Hyung-Woo
Kim Gi-Do
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Abstract
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This study classified 40 of 10 weeks-old male Sprague Dawley rats which have osteoporosis caused by glucocorticoid(GC) induction into four groups of 10 rats and made the subjects medicated them Eucommia ulmoides Oliver and participate in treadmill exercise. Group I was non-treatment after GC induction; Group II was treadmill exercise after GC induction; Group III was Eucommia ulmoides Oliver feeding after GC induction; Group IV was treadmill exercise and Eucommia ulmoides Oliver feeding after GC induction. In the bone mineral density and bone strength test, there was a statistically significant difference between the group I, II, III compared to group IV(p<0.05). In the osteocalcin level as one of bone formation indexes, there was a statistically significant difference between the group I, II, III compared to group IV(p<0.05). In respect to the calcium there was a statistically significant difference between group I, II, III compared to group IV(p<0.05). In respect to histological findings, the group IV showed mild femur disruption and lytic change on femur section. The above results suggests that Eucommia ulmoides Oliver medicated and treadmill exercise is effective to prevention and treatment of osteoporosis.
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KEYWORD
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Osteoporosis, Eucommia ulmoides Oliver, Treadmill exercise, Glucocorticoid
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